持田製薬

Coloplast A/S (Humlebæk, Danmark). 2024 revenue ~DKK25Mrd. Ostomy, continence, wound & skin care. SenSura, SpeediCath, Biatain. Medtech + specialized wound care chemistry. 14K+ employees.

Our multivariate data analysis identified two previously unknown process interactions.

The QbD-based approach reduced the number of out-of-specification batches by 85%.

L'Oréal R&D (Clichy, France). 2024 revenue ~€43B. Cosmetic chemistry: polymers, emulsifiers, UV filters (Mexoryl SX/XL), peptides. Redermic, Revitalift. Active cosmetics: La Roche-Posay, CeraVe. 88K employees.

Our intumescent flame-retardant system achieved UL94 V-0 rating at 1.6 mm thickness.

Photochromic coatings switched from clear to dark in under 5 seconds under UV.

Our spherical crystallization technique improved the powder flowability dramatically.

深圳微芯生物科技股份有限公司。2024年营收约8亿。原创小分子创新药: 西达本胺(实体瘤HDAC抑制剂)、西格列他钠(PPAR激动剂)。中国首个US-FDA批准的原创抗癌药。表观遗传学药物平台。

AkzoNobel Specialty Chemicals (legacy, now Nouryon). History: spun off in 2018, sold to Carlyle. Pioneered surfactants, ethylene oxide derivatives, peroxides, cellulose ethers. Independent since 2018 as Nouryon.

华鲁恒升化工股份有限公司(德州)。2024年营收约350亿。煤化工龙头: 尿素、DMF、醋酸、乙二醇。煤气化平台: 多联产柔性工艺。尼龙6中间体: 己内酰胺。新能源材料: DMC电解液溶剂。

Recordati Industries S.p.A. (Milano, Italia). 2024 revenue ~€2.2B. Rare diseases: Carbaglu, Isturisa, Recorlev. General medicine: Lomir, Zanipress. Founded 1926. Family-controlled.

The drug-drug interaction risk was mitigated by the lack of CYP inhibition.

Volume of distribution at steady state was 3.2 L/kg — tissue distribution is expected.

Livent Corporation (Philadelphia, PA, now part of Arcadium Lithium). Lithium hydroxide, butyllithium, lithium metal. Battery-grade LiOH. LipoLite, LioVedx. Hydroxide process from β-spodumene.

The C-H activation approach shortened our synthesis from 12 to 5 steps.

Navin Fluorine International CRAMS Division (Surat, India). Fluorochemicals CRAMS for global pharma. HFCs (R-134a, R-125), HFOs. Fine chemicals & fluoro-intermediates. Contract research and manufacturing.

Colgate-Palmolive Company (New York, NY). 2024 revenue ~$20.1B. Oral care (fluoride chemistry, silica abrasives), home care (surfactants, enzymes), personal care. Triclosan alternatives. Sensitive teeth: potassium nitrate.

Colgate-Palmolive Company (New York, NY). 2024 revenue ~$20.1B. Oral care (fluoride chemistry, silica abrasives), home care (surfactants, enzymes), personal care. Triclosan alternatives. Sensitive teeth: potassium nitrate.