Anticoagulant drugs Heparin Sodium CAS: 9041-08-1 140iu/150iuProdcut name | Heparin sodium | MOQ | 100g | CAS No. | 9041-08-1 | Appearance | crystalline powder | Molecular Formula | (C12H16NS2Na3)20 | Assay | 99% | Application | Pharma grade or research purpose | Packing | As per your request | Storage | Preserve in tight, light-resistant containers in a cool place | Remarks | NA | Custom synthesis | Available | Supply Ability | 500kg/month |
Heparin sodium may be used in the treatment of acute thromboembolic disease, disseminated intravascular coagulation (DIC). In recent years, heparin has been found to clear blood fat. Heparin sodium has low toxicity and the tendency to spontaneous bleeding is the main risk of heparin overdose. Oral ineffective, must be administered by injection. Intramuscular injection or subcutaneous injection is more irritating, occasionally allergic reaction, exceeding the amount may even cause cardiac arrest;
Heparin Sodium (Heparin Sodium) is Heparin Sodium sulfate glycosaminoglycan anticoagulants.In recent years, studies have shown that heparin and fall hematic fat action.
Heparin sodium is an anticoagulant and sticky polysaccharide substance. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. In human body, it is secreted by mast cells and naturally exists in blood. Heparin sodium can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and fight against the formed thrombin, prevent the transformation of prothrombin into thrombin and the effect of antithrombin. Heparin sodium can delay or prevent blood clotting in vivo and in vitro. The mechanism of its action is very complex, and it affects many links in the process of coagulation. Its role is: (1) inhibit the formation and function of thromboplastin, so as to prevent prothrombin into thrombin; (2) It can inhibit thrombin and other clotting factors in high concentration fashion, and prevent fibrinogen from becoming fibrin; (3) can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is related to the negatively charged sulfate in its molecules, and the positively charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect. Because heparin can activate and release lipoprotein esterase in the body, hydrolyze the triglyceride and low-density lipoprotein of chylomicron, it also has the effect of lowering blood lipid.
Functions and Applications:
1.The treatment of various diseases concurrent disseminated intravascular coagulation early.
2.Prevention of arterial and venous thrombosis and pulmonary embolism.
3.Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina (to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of early reinfarction and infarct extension, reduce mortality).
4.The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5.thrombolytic therapy as maintenance therapy.
6.used for the prevention of blood coagulation and blood bank transfusion of blood and other body save anticoagulants.
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