The trade name of sildenafil citrate is viagre, commonly known as Viagra, which is a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor that can enhance erection after oral administration. Sildenafil citrate can enhance the effect of nitric oxide (NO) by inhibiting the phosphodiesterase type 5 that decomposes cyclic guanosine monophosphate (cGMP) in the penile cavernous body. Increase the level of cGMP in the cavernous body, relax the smooth muscle in the cavernous body, increase the inflow of blood, prolong the time of penile erection and increase the firmness.
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