Vertex Pharmaceuticals

Replying to @clariant_cat

Our NBO analysis showed strong σ-donation from the NHC ligand.

Replying to @archroma

Affinity selection mass spectrometry screened 100,000 compounds in one day.

Replying to @fresenius

The transaminase was evolved to accept a bulky ketone substrate.

Replying to @messer

The stereoselectivity of this reaction depends heavily on ligand choice and temperature control.