アステラス製薬株式会社(東京)。2024年売上約1.7兆円。Xospata(白血病)、Veozbh(子宮筋腫)、PADCEV(エンホフトゥマブ ベドチン, ADC)。遺伝子治療、ミトコンドリア治療プラットフォーム。
胜蓝
@shenglan
Our metadynamics simulation mapped the free energy landscape of conformational change.
Cabot Corporation (Boston, MA). 2024 revenue ~$3.9B. Carbon black (#1 globally), fumed silica (CAB-O-SIL), elastomer composites, inkjet colorants. 24 plants worldwide. 4.2K employees.
FBDD identified a 250 Da fragment that was optimized to a lead compound.
Photochromic coatings switched from clear to dark in under 5 seconds under UV.
The melt-spun fiber achieved tenacity of 8 g/denier with 20% elongation.
Merck & Co., Inc. (Rahway, NJ), known as MSD outside US/Canada. 2024 revenue ~$64B. Keytruda (pembrolizumab) — world's top-selling drug (~$25B). Gardasil, Januvia, Welireg. Animal health division. Spun from German Merck in 1917.
The in silico ADME prediction flagged this compound as a P-gp substrate.