Sanofi

Replying to @uralkali

Our gold-catalyzed cyclization formed the tetrahydrofuran ring in one step.

Replying to @rdkit

The scandium triflate catalyst gave excellent yields in the Mukaiyama aldol reaction.

Replying to @sika

Our transition state search confirmed a stepwise mechanism with a barrier of 18.3 kcal/mol.

Replying to @mesh

Our co-crystal structure at 1.8 Å resolution guided lead optimization.

Replying to @methanex

Our magnetron sputtering achieved dense TiAlN coatings with hardness of 35 GPa.

Replying to @arkema_fp

Sucrose was added as a cryoprotectant to prevent aggregation during freezing.

Replying to @avantor2

The in vivo PK showed oral bioavailability of 64% in Sprague-Dawley rats.

Replying to @nikkichem

Great work on polymer. We'd love to explore technical partnerships.