盐酸罗匹尼罗 更新时间：2022-01-14 10:29:11 常用名 盐酸罗匹尼罗 CAS号 91374-20-8 价钱 ￥需询单/1kg ￥需询单/100g ￥需询单/1ton 纯度 99.0% 备货期 需询单 库存 询单 产物详情（用途，包装等） 用途： Ropinirole hydrochloride(SKF101468 hydrochloride) a selective dopamine D2 receptor inhibitor with IC50 of 29 nM.Target: Dopamine D2 ReceptorRopinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice. Ropinirole (0.05-1.0 mg/kg SC) dose-dependently inhibits the dyskinesias induced by 2-di-n-propylamino-5,6-di-hydroxytetralin in mice. Ropirtirole, at doses of 1 and 10 μg, injected unilaterally directly into the striatum of the rat causes marked, contralateral (away from the side of injection) asymmetry and circling in mice. Ropinirole (0.05-1.0 mg/kg SC or 0.1 mg/kg PO) reverses all motor and behavioural deficits induced by MPTP in marmosets [1]. Ropinirole (2 mg/kg, i.p.) for 7 days increases GSH, catalase and SOD activities in the striatum and protected striatal dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in mice [2]. Ropinirole (0.2 mg/kg, i.p.) improves the use of previously akinetic forelimb and produced robust circling behavior in lesioned rats with striatal over-expression of both D2R and D3R compared to lesioned animals that received blank vector. The subtherapeutic dose of ropinirole generates only modest motor effects in lesioned rats with sole over-expression of D2R or D3R [3]. Ropinirole (1-8 mg t.i.d.) is rapidly and completely absorbed with oral bioavailability of 55%, clearance of 780 mL/min, elimination half-life of 6 hours in healthy volunteer. Since the major route of elimination for Ropinirole is by the CYP enzyme system, mainly by CYP1A2 and also by CYP3A4, inhibition of the former and possibly the latter may reduce the agent's clearance and lead to drug accumulation [4]. 物理化学性子： CAS号：91374-20-8 常用中文名：盐酸罗匹尼罗 常用英文名：Ropinirole hydrochloride 分子式：C16H25ClN2O 分子量：296.836 密度：N/A 沸点：410.5ºC at 760mmHg 熔点：241-243ºC 闪点：N/A 储存条件：Room temp 供应商信息 北京翔宇恒天医药手艺有限公司 认证状态： 未认证供应商 电话： +8610-88755821 地址： 古城南街9号院6号楼2120 区域： 北京市 北京市 石景山区 联系人： 李司理 联系人电话： 13911359480 邮件： marketing@eagleskypharmatech.com 网址： www.eagleskypharmatech.com 主要市场： 全球 北京翔宇恒天医药手艺有限公司是一家专门从事医药质料及其中央体、定制化合物的工艺研发、杂质定做和参比制剂入口的科技型企业。公司与美国专业医药公司互助拥有一个完整的手艺平台，能有用地研发出先导药物。公司研发实验室位于四川成都，在江苏和四川有医药中央体互助生产基地，与海内和外洋多家医药企业确立了耐久互助关系。 公司集科研小试、中试及工业化生产干一体，拥有一批在有机合成、工艺研发、工艺优化、工业生产等领域具备较高理论知识水平以及多年厚实事情履历的专业手艺职员。与美国有近二十年新药研发实战履历的现在有十多名博士和硕士组成的研发和运营团队开办的新药研发公司互助。我们承袭"质量为本，诚信第一"的企业理念，充实行展自身优势，为海内外客户提供优质的手艺、优质的产物和优质的服务。