Edoxaban Tosylate Monohydrate 更新时间：2022-01-07 17:01:03 采购接见：1次 常用名 伊多塞班对甲苯磺酸盐 CAS号 480449-71-6 价钱 ￥需询单/100g ￥需询单/1kg ￥需询单/10kg ￥需询单/25kg 纯度 98.0% 备货期 7天 库存 现货 产物详情（用途，包装等） 用途： Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke preventionIC50 Value:Target: factor XaEdoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention in patients with atrial fibrillation, an elderly population that frequently receives aspirin (ASA) and/or nonsteroidal anti-inflammatory drugs for concurrent illnesses[1].in vitro: Edoxaban PK was not affected by concomitant low-dose ASA or naproxen, but high-dose ASA increased systemic exposure of edoxaban by approximately 30%. The effects of edoxaban on prothrombin time, activated partial thromboplastin time, international normalized ratio, anti-FXa, and intrinsic FXa activity were not influenced by administration with ASA or naproxen. Inhibition of platelet aggregation by high-dose ASA, low-dose ASA, or naproxen was not affected by edoxaban[1].in vivo: Forty-eight subjects, aged 18 to 45 years, received either edoxaban 60 mg once daily × 7 days (n = 24) or digoxin 0.25 mg twice daily × 2 days and once daily × 5 days (n = 24) and then concomitantly for 7 days. Serial blood and urine samples were collected for digoxin and edoxaban concentrations on days 7 and 14. Serial coagulation assays were measured for edoxaban on days 7 and 14. Edoxaban PK parameters demonstrated mild increases in area under the curve and peak concentrations of 9.5% and 15.6%, respectively[2],Clinical trial: Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans was reported[3]. 物理化学性子： CAS号：480449-71-6 常用中文名：伊多塞班对甲苯磺酸盐 常用英文名：edoxaban tosylate 分子式：C31H38ClN7O7S2 分子量：720.259 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 供应商信息 Changzhou Guiding Bio-Tech. Co.,Ltd. 认证状态： 已认证供应商 商品数： 397件 电话： +86 519-86686860 地址： 太湖东路9号创意产业园4栋622室 区域： 江苏省 常州市 新北区 联系人： Liya Liu 联系人电话： +8618602580039 邮件： lly@guiding-bio.com 网址： www.guiding-bio.com 主要市场： 欧洲、南北美、东南亚