FINO2 更新时间：2020-12-18 22:54:27 采购访问：1次 常用名 FINO2 CAS号 869298-31-7 价格 $需询单/100mg $需询单/250mg $需询单/500mg 纯度 98.0% 备货期 3天 库存 现货 产品网页 www.dcchemicals.com/product_show-FINO2.html 产品详情（用途，包装等） FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro, leading to degradation of the endoperoxide moiety, but does not affect the protein levels of iron regulatory proteins, such as IRP2, FTL1, or TFR. FINO2 induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells when used at a concentration of 10 μM and induces ferroptosis in an arachidonic acid lipoxygenase-independent manner. It inhibits cell growth and induces lethality in the NCI-60 panel of cancer cell lines. It is selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells. FINO2 induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells. It induces iron-dependent cell death, an effect that can be blocked by pretreatment with the lipophilic antioxidants ferrostatin-1 and liproxstatin-1 and does not induce markers of apoptosis, necrosis, or autophagy in RS4;11 cells. 供应商信息 DC Chemicals Limited 认证状态： 已认证供应商 商品数： 20124件 电话： 58447131 地址： 浦东新区金豫路100号 地区： 上海市 上海市 浦东新区 联系人： Tony Cao 联系人电话： 862158447131 邮件： sales@dcchemicals.com 网址： www.dcchemicals.com 年贸易额： >1000万 D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use. D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan. We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers. Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.