达比加群酯甲磺酸盐 更新时间：2022-01-13 17:31:35 常用名 甲磺酸达比加群酯 CAS号 872728-81-9 价钱 ￥需询单/1ton 纯度 99.0% 备货期 需询单 库存 询单 产物详情（用途，包装等） 用途： Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.IC50 Value: 4.5 nM (Ki); 10 nM(Thrombin-induced platelet aggregation) [1]in vitro: Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC(50): 10 nM), while showing no inhibitory effect on other platelet-stimulating agents.Thrombin generation in platelet-poor plasma (PPP), measured as the endogenous thrombin potential (ETP) was inhibited concentration-dependently (IC(50): 0.56 microM). Dabigatran demonstrated concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 microM, respectively [1]. in vivo: Dabigatran prolonged the aPTT dose-dependently after intravenous administration in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg). Dose- and time-dependent anticoagulant effects were observed with dabigatran etexilate administered orally to conscious rats (10, 20 and 50 mg/kg) or rhesus monkeys (1, 2.5 or 5 mg/kg), with maximum effects observed between 30 and 120 min after administration, respectively [1]. Patients treated with dabigatran etexilate experienced fewer ischaemic strokes (3.74 dabigatran etexilate vs 3.97 warfarin) and fewer combined intracranial haemorrhages and haemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin) per 100 patient-years [2].Clinical trial: An Evaluation of the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate in Hemodialysis Patients . Phase1 物理化学性子： CAS号：872728-81-9 常用中文名：甲磺酸达比加群酯 常用英文名：Dabigatran etexilate mesylate 分子式：C35H45N7O8S 分子量：723.839 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 供应商信息 北京翔宇恒天医药手艺有限公司 认证状态： 未认证供应商 电话： +8610-88755821 地址： 古城南街9号院6号楼2120 区域： 北京市 北京市 石景山区 联系人： 李司理 联系人电话： 13911359480 邮件： marketing@eagleskypharmatech.com 网址： www.eagleskypharmatech.com 主要市场： 全球 北京翔宇恒天医药手艺有限公司是一家专门从事医药质料及其中央体、定制化合物的工艺研发、杂质定做和参比制剂入口的科技型企业。公司与美国专业医药公司互助拥有一个完整的手艺平台，能有用地研发出先导药物。公司研发实验室位于四川成都，在江苏和四川有医药中央体互助生产基地，与海内和外洋多家医药企业确立了耐久互助关系。 公司集科研小试、中试及工业化生产干一体，拥有一批在有机合成、工艺研发、工艺优化、工业生产等领域具备较高理论知识水平以及多年厚实事情履历的专业手艺职员。与美国有近二十年新药研发实战履历的现在有十多名博士和硕士组成的研发和运营团队开办的新药研发公司互助。我们承袭"质量为本，诚信第一"的企业理念，充实行展自身优势，为海内外客户提供优质的手艺、优质的产物和优质的服务。