CAS 62-44-2 Phenacetin China factory sales low price high purity good quality hot selling safe delivery fast deliverty
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Common Name Phenacetin
CAS Number 62-44-2 Molecular Weight 179.216
Density 1.0±0.1 g/cm3 Boiling Point 323.6±44.0 °C at 760 mmHg
Molecular Formula C10H13NO2
PSA 38.33000
LogP 2.01
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.506
Stability Stable. Incompatible with strong oxidizing agents, strong acids.
Water Solubility 0.076 g/100 mL
Phenacetin, a painkiller, was the world’s first synthetic pharmaceutical drug. It was one of the first painkillers that was not derived from opium while at the same time being absent of antiinflammatory qualities. Phenacetinwas developed in 1878 by an American chemist, Harmon Northrop Morse. It was introduced into the pharmaceutical market in 1887. However, it was withdrawn in 1983 in the United States due to unacceptable levels of interstitial nephritis in patients and potential risks of tumorigenicity. Like in the United States, most Western countries did not ban phenacetin from marketing until 1983. Phenacetin is a component of APC (aspirin-phenacetin-caffeine).
Chemical Properties Acetophenetidin is a fine, white, crystalline powder or solid. Odorless with a slightly bitter taste
Originator Phenacetin ,Environmental Health
Uses Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Uses glycosylation inhibitor
Uses Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years until it was implicated in kidney disease (nephropathy) due to abuse of analgesics and was withdrawn from the market. Phenacetin also was previously used as a stabilizer for hydrogen peroxide in hair-bleaching preparations.
Definition ChEBI: Phenacetin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. It has a role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase 3 inhibitor. It is a member of acetamides and an aromatic ether. It is functionally related to a N-phenylacetamide, a 4-ethoxyaniline and a paracetamol.
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