达巴万星盐酸盐
更新时间：2023-02-22 15:00:55
采购接见：2次
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常用名 |
达巴万星盐酸盐 |
CAS号 |
2227366-51-8 |
| 价钱 |
￥4500.0/1g |
纯度 |
98.0% |
| 备货期 |
1天 |
库存 |
现货 |
产物详情（用途，包装等）
中文名 盐酸道古霉素
英文名 Dalbavancin hydrochloride
别名 盐酸道古霉素
道古霉素盐酸盐
达巴万星盐酸盐
英文别名 Dalbavancin hydrochloride
CAS 2227366-51-8
化学式 C88H101Cl3N10O28
分子量 1853.15
存储条件 under inert gas (nitrogen or Argon) at 2-8°C
物化性子 生物活性 Dalbavancin hydrochloride(MDL-63397 hydrochloride) 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌具有有用的杀菌活性。Dalbavancin hydrochloride 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90 划分为 0.06 μg/mL 和 0.25 μg/mL。2227366-51-8 - 用途与合成方式
开放数据 待核验数据
体外研究
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
体内研究
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
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