Lumateperone (ITI-722/ITI-007) is a novel, first-in-class dual 5HT2A receptor antagonist/dopamine phosphoprotein modulator (DPPM) for schizophrenia. It is an orally available compound which combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors.
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