KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. ► KGP94 inhibits the activity of cathepsin L toward human type I collagen. ► KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. ► Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. ► Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment.
Contact：Wuhan Sun-shine Bio-technologyCorporation Limited Add: Building C16, No.388Gaoxin 2Road, East Lake Hi-tech Development Zone, Wuhan 430200, China Tel: +86-27-65522452 QQ：1973737790 Web:http://www.sun-shinechem.com
| 
