EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM; no inhibition on SIRT3. EX-527 S-enantiomer is the S-enantiomer of EX-527, EX-527 racemic has an IC50 of 98 nM for SIRT1, in the reference paper, Compound 35S has good potency than 35R, so we speculate that EX-527 S enantiomer is the active form vs R enantiomer.
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