GA-017
更新时间：2022-07-31 13:41:19
采购接见：1次
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常用名 |
GA-017 |
CAS号 |
2351906-74-4 |
| 价钱 |
￥需询单/1g |
纯度 |
98.9% |
| 备货期 |
需询单 |
库存 |
询单 |
产物详情（用途，包装等）
用途：
GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth.GA-017 increases the number and size of spheroids of various cell-types in both scaffold-based and scaffold-independent cultures.GA-017 also enhances the ex vivo formation of mouse intestinal organoids.GA-017 facilitates the growth of spheroids and organoids by stabilizing and translocating YAP/TAZ into the cell nucleus.GA-017 inhibits the Hippo pathway to promote YAP/TAZ stabilization and nuclear translocation.GA-017 induces expression of Hippo pathway-related genes such as ANKRD1, CYR61, and CTGF in SKOV3 cells in a time- and dose-dependent manner.GA-017 inhibited the activity of 16 kinases of the AGC family at 100 nM against a panel of 321 diverse kinases.The serine/threonine protein kinases LATS (LATS1/2) phosphorylate YAP/TAZ, key effectors of the growth- and proliferation-regulating Hippo signaling pathway.
物理化学性子：
CAS号：2351906-74-4
常用中文名：GA-017
常用英文名：GA-017
分子式：C18H21N3O4
分子量：343.383
密度：N/A
沸点：N/A
熔点：N/A
闪点：N/A
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