千层纸素A
更新时间：2022-02-11 10:05:28
|
|
常用名 |
千层纸素A |
CAS号 |
480-11-5 |
| 价钱 |
￥需询单/1kg |
纯度 |
99.0% |
| 备货期 |
需询单 |
库存 |
询单 |
产物详情（用途，包装等）
用途：
Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].
物理化学性子：
CAS号：480-11-5
常用中文名：千层纸素A
常用英文名：oroxylin A
分子式：C16H12O5
分子量：284.263
密度：1.4±0.1 g/cm3
沸点：540.9±50.0 °C at 760 mmHg
熔点：195-197ºC
闪点：207.4±23.6 °C
储存条件：2-8°C |
