Edoxaban Tosylate Monohydrate
更新时间：2022-01-07 17:01:03
采购接见：1次
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常用名 |
伊多塞班对甲苯磺酸盐 |
CAS号 |
480449-71-6 |
| 价钱 |
￥需询单/100g ￥需询单/1kg ￥需询单/10kg ￥需询单/25kg |
纯度 |
98.0% |
| 备货期 |
7天 |
库存 |
现货 |
产物详情（用途，包装等）
用途：
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke preventionIC50 Value:Target: factor XaEdoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention in patients with atrial fibrillation, an elderly population that frequently receives aspirin (ASA) and/or nonsteroidal anti-inflammatory drugs for concurrent illnesses[1].in vitro: Edoxaban PK was not affected by concomitant low-dose ASA or naproxen, but high-dose ASA increased systemic exposure of edoxaban by approximately 30%. The effects of edoxaban on prothrombin time, activated partial thromboplastin time, international normalized ratio, anti-FXa, and intrinsic FXa activity were not influenced by administration with ASA or naproxen. Inhibition of platelet aggregation by high-dose ASA, low-dose ASA, or naproxen was not affected by edoxaban[1].in vivo: Forty-eight subjects, aged 18 to 45 years, received either edoxaban 60 mg once daily × 7 days (n = 24) or digoxin 0.25 mg twice daily × 2 days and once daily × 5 days (n = 24) and then concomitantly for 7 days. Serial blood and urine samples were collected for digoxin and edoxaban concentrations on days 7 and 14. Serial coagulation assays were measured for edoxaban on days 7 and 14. Edoxaban PK parameters demonstrated mild increases in area under the curve and peak concentrations of 9.5% and 15.6%, respectively[2],Clinical trial: Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans was reported[3].
物理化学性子：
CAS号：480449-71-6
常用中文名：伊多塞班对甲苯磺酸盐
常用英文名：edoxaban tosylate
分子式：C31H38ClN7O7S2
分子量：720.259
密度：N/A
沸点：N/A
熔点：N/A
闪点：N/A
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