Lycorine hydrochloride
更新时间：2021-10-22 15:23:43
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常用名 |
盐酸石蒜碱 |
CAS号 |
2188-68-3 |
| 价钱 |
￥需询单/1kg |
纯度 |
98.0% |
| 备货期 |
需询单 |
库存 |
询单 |
产物详情（用途，包装等）
用途：
Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2]
物理化学性子：
CAS号：2188-68-3
常用中文名：盐酸石蒜碱
常用英文名：Lycorine hydrochloride
分子式：C16H18ClNO4
分子量：323.77
密度：N/A
沸点：477.4ºC at 760 mmHg
熔点：210-212ºC
闪点：242.5ºC
储存条件：2-8°C |
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