依托咪酯
更新时间：2021-09-28 10:44:01
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常用名 |
依托咪酯 |
CAS号 |
33125-97-2 |
| 价钱 |
￥需询单/1kg |
纯度 |
99.0% |
| 备货期 |
需询单 |
库存 |
询单 |
产物详情（用途，包装等）
用途：
Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response suggests that a major increase in adrenal hormone production may not be necessary during surgery [1]. Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure [2]. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality [3].Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
物理化学性子：
CAS号：33125-97-2
常用中文名：依托咪酯
常用英文名：Etomidate
分子式：C14H16N2O2
分子量：244.289
密度：1.1±0.1 g/cm3
沸点：391.5±17.0 °C at 760 mmHg
熔点：72-74ºC
闪点：190.6±20.9 °C
储存条件：2-8°C |
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