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  • Posted @SELL
  • EMI1 (EGFR MaMTH Inhibitor 1),35773-42-3,DC Chemicals Limited

供应信息 2021-1-7 01:23 164
IP: INNA

EMI1 (EGFR MaMTH Inhibitor 1)

更新时间:2020-12-18 22:54:27 采购访问:1次

常用名 EMI1 CAS号 35773-42-3
价格 $950.0/100mg 纯度 98.0%
备货期 3天 库存 现货
产品网页 http://www.dcchemicals.com/product_show-EMI1.html
 产品详情(用途,包装等)
EMI1 (EGFR MaMTH Inhibitor 1) is a novel EGFR ex19del/T790M/C797S inhibitor.EMI1, while potently reducing the interaction of EGFR triple mutant with Shc1 in our MaMTH-DS assay, did not behave as a TKI and displayed no inhibition of the kinase activity of EGFR triple-mutant protein invitro.EMI1 did, however, more strongly inhibit the viability and increase the caspase 3/7 activ-ity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells, as well as potently reduce PC9 EGFR ex19del/T790M/C797S organ-oid viability.EMI1 had a similar inhibi-tory effect on microtubule plus-end growth in both EGFR-WT and EGFR-C797S triple-mutant cells at 50–100 nM concentration. At 1 µM concentration, EMI1 strongly depolymerized inter-phase microtubules, perturbed spindle formation and induced strong mitotic block in PC9 EGFR ex19del/T790M/C797S cells after 20 h of treatment. EMI1 inhibited interaction of both proteins with EGFR at a level similar to that observed with Shc1, indicating it is not a specific inhibitor of the EGFR-Shc1 PPI interface. Rather, the loss of interaction mediated by EMI1 appears to be due to a more general alteration in EGFR activity.EMI1 induced EGFR degradation, and inhibited the activation of EGFR, ERK, AKT and S6 in PC9-ex19del and PC9-ex19del/T790M cells.

供应商信息

DC Chemicals Limited

认证状态:已认证供应商
商品数:20124件
电话:58447131
地址:浦东新区金豫路100号
地区: 上海市 上海市 浦东新区
联系人:Tony Cao
联系人电话:862158447131
邮件:sales@dcchemicals.com
网址:http://www.dcchemicals.com
年贸易额:>1000万
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.



D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.

We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.





Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.
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