7-Hydroxymethotrexate
更新时间:2020-12-18 22:54:27
采购访问:1次
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常用名 |
氨甲叶酸7-羟基代谢物 |
CAS号 |
5939-37-7 |
价格 |
$需询单/100mg $需询单/250mg $需询单/500mg |
纯度 |
98.0% |
备货期 |
3天 |
库存 |
现货 |
产品网页 |
http://www.dcchemicals.com/product_show-7-Hydroxymethotrexate.html |
产品详情(用途,包装等) 7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models. It and the parent compound rapidly accumulate when all three transporters are absent.2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Various methods have been described to quantify 7-hydroxy MTX levels during cancer therapy to avoid toxicity. |
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