BI-2852
更新时间:2020-12-18 22:54:27
采购访问:1次
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常用名 |
BI-2852 |
CAS号 |
2375482-51-0 |
价格 |
$990.0/100mg $1700.0/250mg $3800.0/1g |
纯度 |
98.0% |
备货期 |
3天 |
库存 |
现货 |
产品网页 |
http://www.dcchemicals.com/product_show-BI-2852.html |
产品详情(用途,包装等) BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) because it binds to a different pocket present in both the active and inactive forms of KRAS. BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells[1]. |
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