ML 314,1448895-09-7,DC Chemicals Limited

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ML 314

更新时间：2020-12-18 22:54:27 采购访问：1次

常用名	ML314	CAS号	1448895-09-7
价格	$需询单/100mg $需询单/250mg $需询单/500mg	纯度	98.0%
备货期	3天	库存	现货
产品网页	http://www.dcchemicals.com/product_show-ML_314.html

产品详情（用途，包装等） ML-314 is a brain penetrant nonpeptidic β-arrestin biased ggonist of the neurotensin NTR1 receptor, which exhibits full agonist behavior against NTR1 (EC50 = 2.0 μM) in the primary assay and selectivity against NTR2. The effect of ML314 is blocked by the NTR1 antagonist SR142948A in a dose-dependent manner. Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay and is thus a biased agonist that activates the β-arrestin pathway rather than the traditional Gq coupled pathway. This bias has distinct biochemical and functional consequences that may lead to physiological advantages. ML314 displays good brain penetration in rodents, and studies examining its in vivo properties are underway.

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ML 314,1448895-09-7,DC Chemicals Limited

ML 314,1448895-09-7,DC Chemicals Limited

ML 314

DC Chemicals Limited

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