CB-1158-analog
更新时间：2020-12-18 22:54:27
采购访问：1次
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常用名 |
CB-1158-analog |
CAS号 |
1345810-21-0 |
| 价格 |
$需询单/100mg $需询单/250mg $需询单/500mg |
纯度 |
98.0% |
| 备货期 |
3天 |
库存 |
现货 |
| 产品网页 |
http://www.dcchemicals.com/product_show-CB-1158-analog.html |
产品详情（用途，包装等）
CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cells, inflammatory cytokines, and expression of interferon-inducible genes. CB-1158 may be potentially useful in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. (see ADDITIONAL INFORMATION in this web page for CB-1158 structure confusion). |
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