GNE-140 racemic 
  
 
  更新时间:2020-12-18 22:54:27 
  采购访问:1次 
   
   
  
  
    
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    常用名 |  
     GNE-140 racemic  |  
    CAS号 |  
     1809794-70-4  |  
     
    
    | 价格 |  
     $需询单/100mg $需询单/250mg $需询单/500mg   |  
    纯度 |  
    98.0% |  
     
    
    | 备货期 |  
    3天 |  
    库存 |  
    现货 |  
     
    
    | 产品网页 |  
    http://www.dcchemicals.com/product_show-GNE-140_racemic.html |  
     
  
   
  
   
    
     产品详情(用途,包装等)  GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.  |  
     
   
   
  
  
  
   
  
  
   
   
   
   
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