CM-4620
更新时间:2020-12-18 22:54:27
采购访问:1次
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常用名 |
CM-4620 |
CAS号 |
1713240-67-5 |
价格 |
$需询单/100mg $需询单/250mg $需询单/500mg |
纯度 |
98.0% |
备货期 |
3天 |
库存 |
现货 |
产品网页 |
http://www.dcchemicals.com/product_show-CM-4620.html |
产品详情(用途,包装等) CM4620 is a selective Orai1 inhibitor, prevents Ca2+ entry in acinar cells. The intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells. CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis. |
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