(-)-ε-Viniferin
更新时间：2020-12-18 22:54:27
采购访问：1次
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常用名 |
epsilon-白藜芦醇脱氢二聚体 |
CAS号 |
62218-08-0 |
| 价格 |
$需询单/100mg $需询单/250mg $需询单/500mg |
纯度 |
98.0% |
| 备货期 |
3天 |
库存 |
现货 |
| 产品网页 |
http://www.dcchemicals.com/product_show-epsilon-Viniferin.html |
产品详情（用途，包装等）
trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol that has been found in various red wines. It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42) fibrils and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures. trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells. It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells. In vivo, trans-ε-viniferin reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity. |
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