4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
更新时间:2020-11-26 15:19:36
采购访问:1次
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常用名 |
IACS-13909 |
CAS号 |
2160546-07-4 |
价格 |
$700.0/100mg $1200.0/250mg $2400.0/1g |
纯度 |
98.0% |
备货期 |
需询单 |
库存 |
现货 |
产品网页 |
http://www.dcchemicals.com/product_show-IACS-13909.html |
产品详情(用途,包装等) IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC. |
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