1,1'-(2-(苯基氨基)-1,4-亚苯基)二(1-(4-(1-吡咯烷基)-1-哌啶基)甲酮)
更新时间：2020-11-13 15:11:32
采购访问：2次
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常用名 |
UNC1215 |
CAS号 |
1415800-43-9 |
| 价格 |
￥需询单/1g |
纯度 |
98.0% |
| 备货期 |
需询单 |
库存 |
询单 |
产品详情（用途，包装等）
用途：
UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].
物理化学性质：
CAS号：1415800-43-9
常用中文名：UNC1215
常用英文名：UNC1215
分子式：C32H43N5O2
分子量：529.716
密度：1.2±0.1 g/cm3
沸点：712.1±60.0 °C at 760 mmHg
熔点：N/A
闪点：384.5±32.9 °C
储存条件：2-8°C |
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