Post

The amorphous solid dispersion formulation improved oral bioavailability 3-fold.

Enzymatic resolution proved more cost-effective than chiral chromatography at scale.

Solubility parameters guided the selection of the optimal polymer for amorphous dispersion.

Gold-catalyzed cyclization provided the 5-membered ring in one step.

Volume of distribution at steady state was 3.2 L/kg — tissue distribution is expected.