CA-4948
更新时间：2023-03-07 14:03:46
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常用名 |
CA-4948 |
CAS号 |
1801343-74-7 |
| 价钱 |
￥1000.0/1g |
纯度 |
98.0% |
| 备货期 |
3天 |
库存 |
现货 |
产物详情（用途，包装等）
Product Name:CA-4948
CAS:1801343-74-7
MF:C21H19N7O3
Package:1g/bottle
一种可逆性激酶抑制剂，在TLR和IL-1R信号级联反映中，调治IRAK4的功效。在体内外实验中，具有优越的药代动力学特征和抗肿瘤活性。CA-4948isapotent,andorallyactiveinterleukin-1receptor-associatedkinase4(IRAK4)inhibitor.CA-4948exhibitedthegreatestefficacyinfourofthefiveABC-DLBChemicalbookCLPDXmodelstestedascomparedtoGBC-DLBCLandABC/GCBDLBCLPDXmodels.Furthermore,CA-4948wasefficaciousinABC-DLBCLPDXtumorscontainingactivatingmutationsinbothTLR/IL-1RandBCRsignalingpathways(MYD88andCD79Bdoublemutants). |
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